Assay Detail
Functional
CHEMBL653162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 8.08 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279260 | RAFABEGRON | 2.0 | 1 | 10.21 |
| CHEMBL282190 | — | — | 1 | 9.96 |
| CHEMBL26183 | — | — | 1 | 9.44 |
| CHEMBL416012 | — | — | 1 | 9.17 |
| CHEMBL283426 | — | — | 1 | 9.04 |
| CHEMBL286819 | — | — | 1 | 9.02 |
| CHEMBL25645 | — | — | 1 | 8.77 |
| CHEMBL25534 | — | — | 1 | 8.77 |
| CHEMBL24851 | — | — | 1 | 8.55 |
| CHEMBL26393 | — | — | 1 | 8.27 |
| CHEMBL24350 | — | — | 1 | 8.00 |
| CHEMBL24615 | — | — | 1 | 7.96 |
| CHEMBL25133 | — | — | 1 | 7.92 |
| CHEMBL25724 | — | — | 1 | 7.92 |
| CHEMBL24967 | — | — | 1 | 7.85 |
| CHEMBL284782 | — | — | 1 | 7.68 |
| CHEMBL429396 | — | — | 1 | 7.66 |
| CHEMBL24414 | — | — | 1 | 7.55 |
| CHEMBL24899 | — | — | 1 | 7.42 |
| CHEMBL24269 | — | — | 1 | 7.02 |
| CHEMBL286818 | — | — | 1 | 6.92 |
| CHEMBL279931 | — | — | 1 | 6.66 |
| CHEMBL25823 | — | — | 1 | 6.62 |
| CHEMBL282039 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279260 | RAFABEGRON | EC50 | = | 0.062 | nM | 10.21 |
| CHEMBL282190 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL26183 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL416012 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL283426 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL286819 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL25645 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL25534 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL24851 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL26393 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL24350 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL24615 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL25133 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL25724 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL24967 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL284782 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL429396 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL24414 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL24899 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL24269 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL286818 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL279931 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL25823 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL282039 | — | EC50 | = | 3300.0 | nM | 5.48 |