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Compound Detail

CHEMBL282190

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CC(Cc1c[nH]c2c(OCC(=O)O)cccc12)NC[C@H](O)c1cccc(Cl)c1

Basic Information

ChEMBL ID CHEMBL282190
Phase Preclinical
Structure Type MOL
InChI Key FHEYFIGWYQJVDR-UWBLVGDVSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

402.9
MW (Da)
3.54
ALogP
4
HBA
4
HBD
94.6
PSA (Ų)
0.44
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H23ClN2O4
MW 402.88
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.62

Activity Summary

EC50 4 meas. best 10.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 10.21 10.085 0.1 2
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.19 8.19 6.4 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.89 7.89 13.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12657269 10.1016/s0960-894x(03)00073-8 Beta-3 adrenergic receptor 2
21170122 10.1007/s00044-009-9257-x Beta-3 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-1 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine