Assay Detail
Functional
CHEMBL651143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro beta-adrenergic activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of glycerol release from adipocytes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Epididymal fat pad |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.13 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32590 | — | — | 1 | 8.52 |
| CHEMBL284782 | — | — | 1 | 8.08 |
| CHEMBL38486 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32590 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL284782 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL38486 | — | EC50 | = | 16.0 | nM | 7.80 |