Assay Detail
Binding
CHEMBL651149
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Inhibition of [125I]-AII binding to Angiotensin II receptor of rat uterine membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.08 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.89 |
| CHEMBL267809 | — | — | 1 | 8.35 |
| CHEMBL9599 | SC-55634 | — | 1 | 8.31 |
| CHEMBL274668 | — | — | 1 | 8.30 |
| CHEMBL430152 | — | — | 1 | 8.30 |
| CHEMBL85595 | — | — | 1 | 8.25 |
| CHEMBL9642 | SC-52892 | — | 1 | 8.19 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.16 |
| CHEMBL276689 | — | — | 1 | 8.03 |
| CHEMBL9714 | SC-51895 | — | 1 | 7.92 |
| CHEMBL276002 | — | — | 1 | 7.85 |
| CHEMBL427808 | — | — | 1 | 7.72 |
| CHEMBL274082 | — | — | 1 | 7.47 |
| CHEMBL9771 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL267809 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL9599 | SC-55634 | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL274668 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL430152 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL85595 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL9642 | SC-52892 | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL315021 | FORASARTAN | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL276689 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL9714 | SC-51895 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL276002 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL427808 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL274082 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL9771 | — | IC50 | = | 45.0 | nM | 7.35 |