Assay Detail
Binding
CHEMBL651182
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Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Female gonad |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity, and in vivo studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.60 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450283 | — | — | 1 | 8.80 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.74 |
| CHEMBL321916 | — | — | 1 | 8.58 |
| CHEMBL432608 | ALPDEM | — | 1 | 8.58 |
| CHEMBL104686 | — | — | 1 | 8.55 |
| CHEMBL126262 | — | — | 1 | 8.55 |
| CHEMBL321069 | — | — | 1 | 8.37 |
| CHEMBL339816 | — | — | 1 | 8.34 |
| CHEMBL340938 | — | — | 1 | 8.24 |
| CHEMBL128407 | — | — | 1 | 8.13 |
| CHEMBL106237 | — | — | 1 | 8.11 |
| CHEMBL128147 | — | — | 1 | 8.10 |
| CHEMBL339530 | — | — | 1 | 8.06 |
| CHEMBL340752 | — | — | 1 | 7.98 |
| CHEMBL129028 | — | — | 1 | 7.88 |
| CHEMBL127057 | — | — | 1 | 7.80 |
| CHEMBL129162 | — | — | 1 | 7.68 |
| CHEMBL129511 | — | — | 1 | 7.64 |
| CHEMBL337917 | — | — | 1 | 7.57 |
| CHEMBL340201 | — | — | 1 | 7.48 |
| CHEMBL341361 | — | — | 1 | 7.48 |
| CHEMBL338378 | — | — | 1 | 7.38 |
| CHEMBL338634 | — | — | 1 | 7.31 |
| CHEMBL320366 | — | — | 1 | 7.02 |
| CHEMBL338442 | — | — | 1 | 6.92 |
| CHEMBL126286 | — | — | 1 | 6.75 |
| CHEMBL127060 | — | — | 1 | 6.52 |
| CHEMBL126730 | — | — | 1 | 6.41 |
| CHEMBL128093 | — | — | 1 | 6.35 |
| CHEMBL128491 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450283 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL481537 | PK-11195 | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL321916 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL432608 | ALPDEM | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL104686 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL126262 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL321069 | — | IC50 | = | 4.266 | nM | 8.37 |
| CHEMBL339816 | — | IC50 | = | 4.571 | nM | 8.34 |
| CHEMBL340938 | — | IC50 | = | 5.754 | nM | 8.24 |
| CHEMBL128407 | — | IC50 | = | 7.413 | nM | 8.13 |
| CHEMBL106237 | — | IC50 | = | 7.762 | nM | 8.11 |
| CHEMBL128147 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL339530 | — | IC50 | = | 8.71 | nM | 8.06 |
| CHEMBL340752 | — | IC50 | = | 10.47 | nM | 7.98 |
| CHEMBL129028 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL127057 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL129162 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL129511 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL337917 | — | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL340201 | — | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL341361 | — | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL338378 | — | IC50 | = | 41.69 | nM | 7.38 |
| CHEMBL338634 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL320366 | — | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL338442 | — | IC50 | = | 120.23 | nM | 6.92 |
| CHEMBL126286 | — | IC50 | = | 177.83 | nM | 6.75 |
| CHEMBL127060 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL126730 | — | IC50 | = | 389.05 | nM | 6.41 |
| CHEMBL128093 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL128491 | — | IC50 | = | 524.81 | nM | 6.28 |
| CHEMBL129101 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL338633 | — | IC50 | = | 1995.26 | nM | 5.70 |