Assay Detail
Functional
CHEMBL651231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency at Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 8.04 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72441 | — | — | 1 | 9.38 |
| CHEMBL70751 | — | — | 1 | 9.30 |
| CHEMBL72768 | — | — | 1 | 8.73 |
| CHEMBL70691 | — | — | 1 | 8.44 |
| CHEMBL72724 | — | — | 1 | 8.22 |
| CHEMBL306792 | — | — | 1 | 8.22 |
| CHEMBL540035 | — | — | 1 | 7.86 |
| CHEMBL553276 | — | — | 1 | 7.21 |
| CHEMBL70634 | — | — | 1 | 7.21 |
| CHEMBL70692 | — | — | 1 | 7.07 |
| CHEMBL71479 | — | — | 1 | 6.85 |
| CHEMBL70740 | — | — | 1 | - |
| CHEMBL74114 | — | — | 1 | - |
| CHEMBL544290 | — | — | 1 | - |
| CHEMBL74467 | — | — | 1 | - |
| CHEMBL70973 | — | — | 1 | - |
| CHEMBL72958 | NS-49 | — | 1 | - |
| CHEMBL71001 | — | — | 1 | - |
| CHEMBL70326 | — | — | 1 | - |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | - |
| CHEMBL542402 | — | — | 1 | - |
| CHEMBL74071 | — | — | 1 | - |
| CHEMBL419448 | — | — | 1 | - |
| CHEMBL302698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72441 | — | EC50 | = | 0.4169 | nM | 9.38 |
| CHEMBL70751 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL72768 | — | EC50 | = | 1.862 | nM | 8.73 |
| CHEMBL70691 | — | EC50 | = | 3.631 | nM | 8.44 |
| CHEMBL72724 | — | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL306792 | — | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL540035 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL553276 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL70634 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL70692 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL71479 | — | EC50 | = | 141.25 | nM | 6.85 |
| CHEMBL70740 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL74114 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL544290 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL74467 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL70973 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL72958 | NS-49 | EC50 | < | 100000.0 | nM | - |
| CHEMBL71001 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL70326 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL762 | OXYMETAZOLINE | EC50 | < | 25118.86 | nM | - |
| CHEMBL542402 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL74071 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL419448 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL302698 | — | EC50 | < | 100000.0 | nM | - |