Assay Detail
Binding
CHEMBL651235
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Binding affinity of compound towards human Alpha-1B adrenergic receptor expressed in rat fibroblast membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.00 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357129 | — | — | 1 | 6.57 |
| CHEMBL13789 | — | — | 1 | 6.13 |
| CHEMBL143562 | — | — | 1 | 6.11 |
| CHEMBL356605 | — | — | 1 | 5.89 |
| CHEMBL420683 | — | — | 1 | 5.69 |
| CHEMBL344294 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357129 | — | IC50 | = | 269.15 | nM | 6.57 |
| CHEMBL13789 | — | IC50 | = | 741.31 | nM | 6.13 |
| CHEMBL143562 | — | IC50 | = | 776.25 | nM | 6.11 |
| CHEMBL356605 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL420683 | — | IC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL344294 | — | IC50 | = | 2454.71 | nM | 5.61 |