Assay Detail
Binding
CHEMBL651236
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In vitro binding affinity against human Alpha-1B adrenergic receptor expressed in rat-1 fibroblasts
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.43 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155327 | — | — | 1 | 6.88 |
| CHEMBL351542 | — | — | 1 | 6.79 |
| CHEMBL117381 | — | — | 1 | 6.64 |
| CHEMBL154023 | — | — | 1 | 6.49 |
| CHEMBL155326 | — | — | 1 | 6.35 |
| CHEMBL154298 | — | — | 1 | 6.23 |
| CHEMBL156661 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155327 | — | IC50 | = | 131.83 | nM | 6.88 |
| CHEMBL351542 | — | IC50 | = | 162.18 | nM | 6.79 |
| CHEMBL117381 | — | IC50 | = | 229.09 | nM | 6.64 |
| CHEMBL154023 | — | IC50 | = | 323.59 | nM | 6.49 |
| CHEMBL155326 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL154298 | — | IC50 | = | 588.84 | nM | 6.23 |
| CHEMBL156661 | — | IC50 | = | 2187.76 | nM | 5.66 |