Assay Detail
Binding
CHEMBL651251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonistic activity against specific binding of [3H]-Ro-15-1788 to GABA-A Benzodiazepine receptor in rat cortex
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies at the benzodiazepine receptor (BZR): a comparison of the substitutent effects of pyrazoloquinolinone analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.52 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19732 | CGS-8216 | — | 1 | 9.89 |
| CHEMBL3144739 | — | — | 1 | 9.42 |
| CHEMBL20042 | CGS-9896 | — | 1 | 9.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19732 | CGS-8216 | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3144739 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL20042 | CGS-9896 | IC50 | = | 0.56 | nM | 9.25 |