Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL651305

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of human serum Butyrylcholinesterase.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.
Rampa A, Piazzi L, Belluti F, Gobbi S, Bisi A, Bartolini M, Andrisano V, Cavrini V, Cavalli A, Recanatini M, Valenti P.
J Med Chem (2001) 44 : 3810 -3820
PubMed 11689067 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.63 8.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL127857 1 8.48
CHEMBL127465 1 8.41
CHEMBL340171 1 8.31
CHEMBL340228 1 8.12
CHEMBL124933 1 7.86
CHEMBL543655 1 7.78
CHEMBL544126 1 7.66
CHEMBL94 PHYSOSTIGMINE 3.0 1 7.64
CHEMBL539045 1 7.61
CHEMBL544592 1 7.61
CHEMBL557405 1 7.60
CHEMBL544823 1 7.50
CHEMBL540833 1 7.47
CHEMBL124156 1 7.37
CHEMBL542467 1 7.32
CHEMBL542220 1 6.69
CHEMBL553803 1 6.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL127857 IC50 = 3.3 nM 8.48
CHEMBL127465 IC50 = 3.9 nM 8.41
CHEMBL340171 IC50 = 4.9 nM 8.31
CHEMBL340228 IC50 = 7.5 nM 8.12
CHEMBL124933 IC50 = 13.9 nM 7.86
CHEMBL543655 IC50 = 16.5 nM 7.78
CHEMBL544126 IC50 = 22.1 nM 7.66
CHEMBL94 PHYSOSTIGMINE IC50 = 23.1 nM 7.64
CHEMBL539045 IC50 = 24.8 nM 7.61
CHEMBL544592 IC50 = 24.5 nM 7.61
CHEMBL557405 IC50 = 25.2 nM 7.60
CHEMBL544823 IC50 = 31.6 nM 7.50
CHEMBL540833 IC50 = 34.1 nM 7.47
CHEMBL124156 IC50 = 42.6 nM 7.37
CHEMBL542467 IC50 = 48.3 nM 7.32
CHEMBL542220 IC50 = 205.0 nM 6.69
CHEMBL553803 IC50 = 529.0 nM 6.28