Assay Detail
Functional
CHEMBL651396
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Effective concentration of compound achieving 50% protection in CEM cell lines against the cytopathic effect of HIV-1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of stavudine amino acid ester prodrugs with broad-spectrum chemotherapeutic properties for the effective treatment of HIV/AIDS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.73 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.05 |
| CHEMBL174914 | — | — | 1 | 6.46 |
| CHEMBL174915 | — | — | 1 | 6.40 |
| CHEMBL433772 | — | — | 1 | 6.28 |
| CHEMBL175147 | — | — | 1 | 4.21 |
| CHEMBL174488 | — | — | 1 | 4.00 |
| CHEMBL174698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL174914 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL174915 | — | EC50 | = | 402.0 | nM | 6.40 |
| CHEMBL433772 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL175147 | — | EC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL174488 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL174698 | — | EC50 | < | 63.6 | nM | - |