Assay Detail
Binding
CHEMBL651412
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Compound was evaluated for beta-lactamase inhibition activity of Escherichia coli after 15 min of pre-incubation with the enzyme at 37 degree C
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of novel penem sulfoxides and sulfones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.64 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.40 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 6.10 |
| CHEMBL67925 | — | — | 1 | 5.00 |
| CHEMBL419441 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL403 | SULBACTAM | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL67925 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL419441 | — | IC50 | = | 90000.0 | nM | 4.05 |