Assay Detail
Binding
CHEMBL651415
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Compound was tested for the inhibition of beta-lactamase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.48 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221 | SULCONAZOLE | 4.0 | 1 | 4.85 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 4.70 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.70 |
| CHEMBL808 | ECONAZOLE | 4.0 | 1 | 4.60 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.40 |
| CHEMBL1239 | BENZYL BENZOATE | 4.0 | 1 | 4.05 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 4.05 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | - |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | - |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221 | SULCONAZOLE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1239 | BENZYL BENZOATE | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL686 | MEFENAMIC ACID | IC50 | = | 350000.0 | nM | - |
| CHEMBL157101 | KETOCONAZOLE | IC50 | > | 150000.0 | nM | - |
| CHEMBL472 | GLYBURIDE | IC50 | = | 300000.0 | nM | - |
| CHEMBL106 | FLUCONAZOLE | IC50 | > | 400000.0 | nM | - |