Assay Detail
Functional
CHEMBL651595
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In vitro cytotoxicity against BALB/c 3T3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemically stable N-methyl-4-(alkylthio)cyclophosphamide derivatives as prodrugs of 4-hydroxycyclophosphamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.27 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168659 | — | — | 1 | 6.22 |
| CHEMBL445318 | — | — | 1 | 5.77 |
| CHEMBL168859 | — | — | 1 | 4.66 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168659 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL445318 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL168859 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 37600.0 | nM | 4.42 |