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Assay Detail

CHEMBL651613

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective dose for relaxation of guinea pig trachea.
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Trachea
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Beta-2 adrenergic receptor (CHEMBL5414)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Ruffolo RR, Bondinell W, Hieble JP.
J Med Chem (1995) 38 : 3681 -3716
PubMed 7562902 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 7.09 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL679 EPINEPHRINE 4.0 2 7.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL679 EPINEPHRINE EC50 = 15.0 nM 7.82
CHEMBL679 EPINEPHRINE EC50 = 436.0 nM 6.36