Assay Detail
Functional
CHEMBL651630
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Antagonist activity against beta-2 adrenergic receptor in isolated guinea pig trachea
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Role of the (acyloxy)methyl moiety in eliciting the adrenergic beta-blocking activity of 3-(acyloxy)propanolamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.62 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156603 | — | — | 1 | 7.72 |
| CHEMBL289093 | BUTOXAMINE | 2.0 | 1 | 6.89 |
| CHEMBL156147 | — | — | 1 | 6.33 |
| CHEMBL157557 | — | — | 1 | 5.64 |
| CHEMBL156682 | — | — | 1 | 5.60 |
| CHEMBL156271 | — | — | 1 | 5.37 |
| CHEMBL156683 | — | — | 1 | 5.00 |
| CHEMBL156304 | — | — | 1 | 4.58 |
| CHEMBL449651 | — | — | 1 | 4.54 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156603 | — | Kd | = | 19.05 | nM | 7.72 |
| CHEMBL289093 | BUTOXAMINE | Kd | = | 128.82 | nM | 6.89 |
| CHEMBL156147 | — | Kd | = | 467.74 | nM | 6.33 |
| CHEMBL157557 | — | Kd | = | 2290.87 | nM | 5.64 |
| CHEMBL156682 | — | Kd | = | 2511.89 | nM | 5.60 |
| CHEMBL156271 | — | Kd | = | 4265.8 | nM | 5.37 |
| CHEMBL156683 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL156304 | — | Kd | = | 26302.68 | nM | 4.58 |
| CHEMBL449651 | — | Kd | = | 28840.32 | nM | 4.54 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 31622.78 | nM | 4.50 |