Assay Detail
Functional
CHEMBL651631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal strips
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 7.38 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287766 | — | — | 1 | 8.62 |
| CHEMBL41839 | — | — | 1 | 8.52 |
| CHEMBL40626 | — | — | 1 | 8.38 |
| CHEMBL40783 | — | — | 1 | 8.20 |
| CHEMBL289858 | — | — | 1 | 7.98 |
| CHEMBL289868 | — | — | 1 | 7.41 |
| CHEMBL41378 | — | — | 1 | 7.14 |
| CHEMBL289093 | BUTOXAMINE | 2.0 | 1 | 6.89 |
| CHEMBL431713 | — | — | 1 | 6.81 |
| CHEMBL40971 | — | — | 1 | 6.76 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287766 | — | Kd | = | 2.399 | nM | 8.62 |
| CHEMBL41839 | — | Kd | = | 3.02 | nM | 8.52 |
| CHEMBL40626 | — | Kd | = | 4.169 | nM | 8.38 |
| CHEMBL40783 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL289858 | — | Kd | = | 10.47 | nM | 7.98 |
| CHEMBL289868 | — | Kd | = | 38.9 | nM | 7.41 |
| CHEMBL41378 | — | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL289093 | BUTOXAMINE | Kd | = | 128.82 | nM | 6.89 |
| CHEMBL431713 | — | Kd | = | 154.88 | nM | 6.81 |
| CHEMBL40971 | — | Kd | = | 173.78 | nM | 6.76 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 31622.78 | nM | 4.50 |