Assay Detail
Binding
CHEMBL651655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to displace [3H]dihydroalprenolol form beta adrenergic receptor site in guinea pig cerebral cortical membranes.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Adrenergic receptor beta; ADRB1 & ADRB3 (CHEMBL2097169) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and adrenergic activity of ring-fluorinated phenylephrines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.00 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302451 | — | — | 1 | 5.40 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 4.89 |
| CHEMBL62072 | — | — | 1 | 4.72 |
| CHEMBL61372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302451 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1215 | PHENYLEPHRINE | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL62072 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL61372 | — | Ki | = | 180000.0 | nM | - |