Assay Detail
Binding
CHEMBL651728
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In vitro anticholinesterase activity against butyrylcholinesterase from torpedo californica
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.11 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343780 | — | — | 1 | 5.68 |
| CHEMBL146254 | — | — | 1 | 5.64 |
| CHEMBL335133 | — | — | 1 | 5.60 |
| CHEMBL424100 | — | — | 1 | 5.44 |
| CHEMBL344593 | — | — | 1 | 5.39 |
| CHEMBL137039 | — | — | 1 | 5.37 |
| CHEMBL359415 | — | — | 1 | 5.33 |
| CHEMBL409854 | SALIGCINNAMIDE | — | 1 | 5.32 |
| CHEMBL422098 | — | — | 1 | 4.99 |
| CHEMBL147346 | — | — | 1 | 4.78 |
| CHEMBL413039 | — | — | 1 | 4.75 |
| CHEMBL421920 | — | — | 1 | 4.74 |
| CHEMBL146080 | — | — | 1 | 4.62 |
| CHEMBL343365 | — | — | 1 | 4.54 |
| CHEMBL343054 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343780 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL146254 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL335133 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL424100 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL344593 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL137039 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL359415 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL409854 | SALIGCINNAMIDE | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL422098 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL147346 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL413039 | — | IC50 | = | 17990.0 | nM | 4.75 |
| CHEMBL421920 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL146080 | — | IC50 | = | 23780.0 | nM | 4.62 |
| CHEMBL343365 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL343054 | — | IC50 | = | 38360.0 | nM | 4.42 |