Assay Detail
Binding
CHEMBL651948
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In vitro inhibition of [3H]flunitrazepam binding to GABA-A Benzodiazepine receptor of rat cerebral cortex membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.22 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10483 | — | — | 1 | 9.30 |
| CHEMBL10195 | — | — | 1 | 9.05 |
| CHEMBL1518572 | — | — | 1 | 9.00 |
| CHEMBL10534 | — | — | 1 | 8.64 |
| CHEMBL10597 | — | — | 1 | 8.05 |
| CHEMBL268262 | — | — | 1 | 8.00 |
| CHEMBL273464 | — | — | 1 | 7.66 |
| CHEMBL276377 | — | — | 1 | 6.03 |
| CHEMBL10701 | — | — | 1 | - |
| CHEMBL10638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10483 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL10195 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1518572 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL10534 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL10597 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL268262 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL273464 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL276377 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL10701 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL10638 | — | IC50 | > | 5000.0 | nM | - |