Assay Detail
Binding
CHEMBL651955
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Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.06 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 8.54 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.07 |
| CHEMBL318513 | — | — | 1 | 6.10 |
| CHEMBL102754 | — | — | 1 | 5.84 |
| CHEMBL320690 | — | — | 1 | 5.82 |
| CHEMBL103092 | — | — | 1 | 5.80 |
| CHEMBL101914 | — | — | 1 | 5.73 |
| CHEMBL102720 | — | — | 1 | 5.73 |
| CHEMBL430855 | — | — | 1 | 5.67 |
| CHEMBL102403 | — | — | 1 | 5.63 |
| CHEMBL102541 | — | — | 1 | 5.59 |
| CHEMBL286595 | — | — | 1 | 5.57 |
| CHEMBL101907 | — | — | 1 | 5.46 |
| CHEMBL317921 | — | — | 1 | 5.23 |
| CHEMBL103232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL103 | PROGESTERONE | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL318513 | — | Ki | = | 795.0 | nM | 6.10 |
| CHEMBL102754 | — | Ki | = | 1457.0 | nM | 5.84 |
| CHEMBL320690 | — | Ki | = | 1526.0 | nM | 5.82 |
| CHEMBL103092 | — | Ki | = | 1581.0 | nM | 5.80 |
| CHEMBL101914 | — | Ki | = | 1856.0 | nM | 5.73 |
| CHEMBL102720 | — | Ki | = | 1860.0 | nM | 5.73 |
| CHEMBL430855 | — | Ki | = | 2138.0 | nM | 5.67 |
| CHEMBL102403 | — | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL102541 | — | Ki | = | 2584.0 | nM | 5.59 |
| CHEMBL286595 | — | Ki | = | 2685.0 | nM | 5.57 |
| CHEMBL101907 | — | Ki | = | 3499.0 | nM | 5.46 |
| CHEMBL317921 | — | Ki | = | 5831.0 | nM | 5.23 |
| CHEMBL103232 | — | Ki | > | 10000.0 | nM | - |