Assay Detail
Binding
CHEMBL651976
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Alpha-2 adrenergic receptor pA2 value against clonidine in vitro experiment in rat vas deferens
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.49 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.38 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 8.14 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Kd | = | 4.169 | nM | 8.38 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 7.244 | nM | 8.14 |
| CHEMBL2 | PRAZOSIN | Kd | = | 1148.15 | nM | 5.94 |