Assay Detail
Binding
CHEMBL651986
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Binding affinity against rat Alpha-1 adrenergic receptor.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.67 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9921 | — | — | 1 | 7.50 |
| CHEMBL273923 | — | — | 1 | 7.16 |
| CHEMBL9669 | — | — | 1 | 7.08 |
| CHEMBL9467 | — | — | 1 | 7.02 |
| CHEMBL9746 | — | — | 1 | 6.97 |
| CHEMBL9870 | — | — | 1 | 6.93 |
| CHEMBL9452 | — | — | 1 | 6.86 |
| CHEMBL276156 | — | — | 1 | 6.78 |
| CHEMBL275943 | — | — | 1 | 6.67 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 6.63 |
| CHEMBL274866 | — | — | 1 | 6.47 |
| CHEMBL9429 | — | — | 1 | 6.43 |
| CHEMBL266250 | — | — | 1 | 6.29 |
| CHEMBL9666 | — | — | 1 | 6.29 |
| CHEMBL269784 | — | — | 1 | 6.17 |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | 6.10 |
| CHEMBL269521 | MK-212 | — | 1 | 6.04 |
| CHEMBL267153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9921 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL273923 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL9669 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL9467 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL9746 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL9870 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL9452 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL276156 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL275943 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL274866 | — | Ki | = | 337.0 | nM | 6.47 |
| CHEMBL9429 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL266250 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL9666 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL269784 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL9434 | PHENYLPIPERAZINE | Ki | = | 794.0 | nM | 6.10 |
| CHEMBL269521 | MK-212 | Ki | = | 913.0 | nM | 6.04 |
| CHEMBL267153 | — | Ki | > | 1000.0 | nM | - |