Assay Detail
Binding
CHEMBL651992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards cloned human Alpha-1B adrenergic receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.22 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62045 | — | — | 1 | 7.01 |
| CHEMBL41677 | — | — | 1 | 6.77 |
| CHEMBL59590 | — | — | 1 | 6.24 |
| CHEMBL62249 | — | — | 1 | 5.82 |
| CHEMBL61643 | — | — | 1 | 5.75 |
| CHEMBL299914 | — | — | 1 | 5.72 |
| CHEMBL301416 | — | — | 1 | - |
| CHEMBL60452 | — | — | 1 | - |
| CHEMBL43799 | — | — | 1 | - |
| CHEMBL44124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62045 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL41677 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL59590 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL62249 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL61643 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL299914 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL301416 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL60452 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL43799 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL44124 | — | Ki | > | 2000.0 | nM | - |