Assay Detail
Binding
CHEMBL651999
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The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1B adrenergic receptor in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.14 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.55 |
| CHEMBL49851 | — | — | 1 | 7.87 |
| CHEMBL301078 | — | — | 1 | 7.82 |
| CHEMBL51074 | — | — | 1 | 7.81 |
| CHEMBL301726 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL49851 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL301078 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL51074 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL301726 | — | Ki | = | 22.1 | nM | 7.66 |