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Assay Detail

CHEMBL652052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human beta-3 adrenergic receptor expressed in CHO cells
ChEMBL ↗
48
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-3 adrenergic receptor (CHEMBL246) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

BMS-201620: a selective beta 3 agonist.
Washburn WN, Sun CQ, Bisacchi G, Wu G, Cheng PT, Sher PM, Ryono D, Gavai AV, Poss K, Girotra RN, McCann PJ, Mikkilineni AB, Dejneka TC, Wang TC, Merchant Z, Morella M, Arbeeny CM, Harper TW, Slusarchyk DA, Skwish S, Russell AD, Allen GT, Tesfamariam B, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Young D, Dickinson KE, Seymour AA.
Bioorg Med Chem Lett (2004) 14 : 3525 -3529
PubMed 15177466 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 48 6.59 8.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL323938 — — 1 8.06
CHEMBL332529 — — 1 7.96
CHEMBL119120 — — 1 7.85
CHEMBL115628 — — 1 7.77
CHEMBL434223 — — 1 7.77
CHEMBL119533 — — 1 7.72
CHEMBL326820 — — 1 7.70
CHEMBL116294 — — 1 7.64
CHEMBL118121 — — 1 7.62
CHEMBL119786 — — 1 7.55
CHEMBL333334 — — 2 7.48
CHEMBL116715 — — 1 7.36
CHEMBL332632 — — 1 7.34
CHEMBL115627 — — 1 7.33
CHEMBL333551 — — 1 7.29
CHEMBL115538 — — 1 7.21
CHEMBL117737 — — 1 7.15
CHEMBL117577 — — 2 7.11
CHEMBL102836 — — 1 7.09
CHEMBL118216 — — 1 7.05
CHEMBL325425 — — 1 7.03
CHEMBL119070 — — 1 6.94
CHEMBL118675 — — 1 6.85
CHEMBL116080 — — 1 6.72
CHEMBL418867 — — 1 6.58
CHEMBL119860 — — 1 6.47
CHEMBL118834 — — 1 6.43
CHEMBL330924 — — 1 6.43
CHEMBL115424 — — 1 6.42
CHEMBL115972 — — 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL323938 — Ki = 8.8 nM 8.06
CHEMBL332529 — Ki = 11.0 nM 7.96
CHEMBL119120 — Ki = 14.0 nM 7.85
CHEMBL115628 — Ki = 17.0 nM 7.77
CHEMBL434223 — Ki = 17.0 nM 7.77
CHEMBL119533 — Ki = 19.0 nM 7.72
CHEMBL326820 — Ki = 20.0 nM 7.70
CHEMBL116294 — Ki = 23.0 nM 7.64
CHEMBL118121 — Ki = 24.0 nM 7.62
CHEMBL119786 — Ki = 28.0 nM 7.55
CHEMBL333334 — Ki = 33.0 nM 7.48
CHEMBL116715 — Ki = 44.0 nM 7.36
CHEMBL332632 — Ki = 46.0 nM 7.34
CHEMBL115627 — Ki = 47.0 nM 7.33
CHEMBL333551 — Ki = 51.0 nM 7.29
CHEMBL115538 — Ki = 61.0 nM 7.21
CHEMBL117737 — Ki = 71.0 nM 7.15
CHEMBL117577 — Ki = 77.0 nM 7.11
CHEMBL102836 — Ki = 81.0 nM 7.09
CHEMBL118216 — Ki = 89.0 nM 7.05
CHEMBL325425 — Ki = 93.0 nM 7.03
CHEMBL119070 — Ki = 115.0 nM 6.94
CHEMBL118675 — Ki = 142.0 nM 6.85
CHEMBL116080 — Ki = 190.0 nM 6.72
CHEMBL418867 — Ki = 260.0 nM 6.58
CHEMBL333334 — Ki = 280.0 nM 6.55
CHEMBL119860 — Ki = 340.0 nM 6.47
CHEMBL117577 — Ki = 370.0 nM 6.43
CHEMBL118834 — Ki = 370.0 nM 6.43
CHEMBL330924 — Ki = 370.0 nM 6.43
CHEMBL115424 — Ki = 380.0 nM 6.42
CHEMBL115972 — Ki = 400.0 nM 6.40
CHEMBL326612 — Ki = 450.0 nM 6.35
CHEMBL117596 — Ki = 490.0 nM 6.31
CHEMBL331027 — Ki = 520.0 nM 6.28
CHEMBL119875 — Ki = 950.0 nM 6.02
CHEMBL261933 — Ki = 1800.0 nM 5.75
CHEMBL119128 — Ki = 2200.0 nM 5.66
CHEMBL118287 — Ki = 2910.0 nM 5.54
CHEMBL119831 — Ki = 3100.0 nM 5.51
CHEMBL325853 — Ki = 3100.0 nM 5.51
CHEMBL118336 — Ki = 7000.0 nM 5.16
CHEMBL118069 — Ki = 8200.0 nM 5.09
CHEMBL333879 — Ki = 9600.0 nM 5.02
CHEMBL119210 — Ki = 10000.0 nM 5.00
CHEMBL2111776 — Ki = 14100.0 nM 4.85
CHEMBL2111775 — Ki = 30000.0 nM 4.52
CHEMBL119539 — Ki = 33000.0 nM 4.48