Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL119860

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc([C@](C)(NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)C(=O)Nc2cccc(O)c2)cc1

Basic Information

ChEMBL ID CHEMBL119860
Phase Preclinical
Structure Type MOL
InChI Key FCHYVYSFRFRLIW-ZCYQVOJMSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

515.6
MW (Da)
2.65
ALogP
8
HBA
6
HBD
157.2
PSA (Ų)
0.23
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H29N3O7S
MW 515.59
Aromatic Rings 3
Heavy Atoms 36
NP-Likeness -0.63

Activity Summary

Ki 1 meas. best 6.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
Ki 6.47 6.47 340.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15177466 10.1016/j.bmcl.2004.04.074 Beta-3 adrenergic receptor 1
15177466 10.1016/j.bmcl.2004.04.074 Adrenergic receptor beta; ADRB1 & ADRB3 1
15177466 10.1016/j.bmcl.2004.04.074 Beta-2 adrenergic receptor and beta-3 adrenergic receptor 1
15177466 10.1016/j.bmcl.2004.04.074 Beta-1 adrenergic receptor 1
15177466 10.1016/j.bmcl.2004.04.074 Cavia porcellus 1
15177466 10.1016/j.bmcl.2004.04.074 No relevant target 1

Data from ChEMBL 36 via Core Engine