Assay Detail
Functional
CHEMBL652222
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Compound was tested for inhibition of Escherichia coli AmpC, class C of Beta-lactamase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.99 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | — | 1 | 5.82 |
| CHEMBL333581 | — | — | 1 | 5.77 |
| CHEMBL124960 | — | — | 1 | 5.52 |
| CHEMBL123702 | — | — | 1 | 5.28 |
| CHEMBL2111804 | — | — | 1 | 5.28 |
| CHEMBL123029 | — | — | 1 | 5.00 |
| CHEMBL333078 | — | — | 1 | 4.68 |
| CHEMBL124227 | — | — | 1 | 4.32 |
| CHEMBL124507 | — | — | 1 | 4.14 |
| CHEMBL124961 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL333581 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL124960 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL123702 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2111804 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL123029 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL333078 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL124227 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL124507 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL124961 | — | IC50 | = | 81000.0 | nM | 4.09 |