Assay Detail
Binding
CHEMBL652240
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Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
--didehydrotryptophan as a surrogate for -methyltryptophan in CCK peptoids related to CI-988.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.37 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138534 | — | — | 1 | 9.82 |
| CHEMBL2115544 | — | — | 1 | 9.52 |
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 8.77 |
| CHEMBL368803 | — | — | 1 | 7.89 |
| CHEMBL2115543 | — | — | 1 | 7.22 |
| CHEMBL177081 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138534 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2115544 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2062154 | CI-988 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL368803 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2115543 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL177081 | — | IC50 | = | 99.0 | nM | 7.00 |