Assay Detail
Binding
CHEMBL652241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Cholecystokinin analogues: The ergopeptine alkaloids as models of the active conformation of CCK
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.29 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278032 | — | — | 1 | 6.46 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 1 | 4.77 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 1 | 4.64 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 1 | - |
| CHEMBL18727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278032 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | > | 80000.0 | nM | - |
| CHEMBL18727 | — | IC50 | > | 80000.0 | nM | - |