Assay Detail
Binding
CHEMBL652247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.75 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263969 | — | — | 1 | 8.77 |
| CHEMBL145133 | — | — | 1 | 7.88 |
| CHEMBL356898 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263969 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL145133 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL356898 | — | IC50 | = | 259.0 | nM | 6.59 |