Assay Detail
Functional
CHEMBL652263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for antagonism of Angiotensin II-contracted rabbit aortic rings. Compound shows competitive receptor Antagonism.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.26 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276689 | — | — | 1 | 8.70 |
| CHEMBL9642 | SC-52892 | — | 1 | 8.68 |
| CHEMBL9714 | SC-51895 | — | 1 | 8.65 |
| CHEMBL276002 | — | — | 1 | 8.30 |
| CHEMBL9771 | — | — | 1 | 8.10 |
| CHEMBL274082 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276689 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL9642 | SC-52892 | Kd | = | 2.089 | nM | 8.68 |
| CHEMBL9714 | SC-51895 | Kd | = | 2.239 | nM | 8.65 |
| CHEMBL276002 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL9771 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL274082 | — | Kd | = | 79.43 | nM | 7.10 |