Assay Detail
Functional
CHEMBL652266
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In vitro antagonist activity against Angiotensin II receptor was measured in the rabbit aorta strip assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 7.48 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 9.10 |
| CHEMBL2371400 | — | — | 1 | 8.79 |
| CHEMBL2371388 | — | — | 1 | 8.78 |
| CHEMBL2371393 | — | — | 1 | 8.25 |
| CHEMBL2371409 | — | — | 1 | 7.75 |
| CHEMBL2371401 | — | — | 1 | 7.75 |
| CHEMBL2371399 | — | — | 1 | 7.50 |
| CHEMBL2371394 | — | — | 1 | 7.50 |
| CHEMBL2371411 | — | — | 1 | 7.50 |
| CHEMBL2371425 | — | — | 1 | 7.40 |
| CHEMBL2371429 | — | — | 1 | 7.10 |
| CHEMBL2371392 | — | — | 1 | 7.00 |
| CHEMBL2371391 | — | — | 1 | 7.00 |
| CHEMBL2371396 | — | — | 1 | 6.75 |
| CHEMBL2371415 | — | — | 1 | 6.75 |
| CHEMBL2371406 | — | — | 1 | 6.20 |
| CHEMBL2371417 | — | — | 1 | 6.00 |
| CHEMBL2371424 | — | — | 1 | - |
| CHEMBL2371434 | — | — | 1 | - |
| CHEMBL2371435 | — | — | 1 | - |
| CHEMBL2371403 | — | — | 1 | - |
| CHEMBL2371433 | — | — | 1 | - |
| CHEMBL2371413 | — | — | 1 | - |
| CHEMBL2371423 | — | — | 1 | - |
| CHEMBL2371384 | — | — | 1 | - |
| CHEMBL2371426 | — | — | 1 | - |
| CHEMBL1702539 | — | — | 1 | - |
| CHEMBL2112029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL2371400 | — | Kd | = | 1.622 | nM | 8.79 |
| CHEMBL2371388 | — | Kd | = | 1.66 | nM | 8.78 |
| CHEMBL2371393 | — | Kd | = | 5.623 | nM | 8.25 |
| CHEMBL2371409 | — | Kd | = | 17.78 | nM | 7.75 |
| CHEMBL2371401 | — | Kd | = | 17.78 | nM | 7.75 |
| CHEMBL2371399 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL2371394 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL2371411 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL2371425 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL2371429 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL2371392 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL2371391 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL2371396 | — | Kd | = | 177.83 | nM | 6.75 |
| CHEMBL2371415 | — | Kd | = | 177.83 | nM | 6.75 |
| CHEMBL2371406 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL2371417 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL2371424 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371434 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371435 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371403 | — | Kd | = | 1000000000.0 | nM | - |
| CHEMBL2371433 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371413 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371423 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2371384 | — | Kd | = | 1000000000.0 | nM | - |
| CHEMBL2371426 | — | Kd | = | 1000000000.0 | nM | - |
| CHEMBL1702539 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2112029 | — | Kd | << | 6.0 | nM | - |