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Assay Detail

CHEMBL652268

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for the antagonism of AII-induced contraction in rabbit endothelium-denuded aorta strips
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Aorta
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094256)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Nonpeptide angiotensin II receptor antagonists. Synthesis, in vitro activity, and molecular modeling studies of N-[(heterobiaryl)methyl] imidazoles.
Salimbeni A, Canevotti R, Paleari F, Bonaccorsi F, Renzetti AR, Belvisi L, Bravi G, Scolastico C.
J Med Chem (1994) 37 : 3928 -3938
PubMed 7966154 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 5.95 6.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL274447 1 6.90
CHEMBL129225 1 6.10
CHEMBL128291 1 6.00
CHEMBL339044 1 5.80
CHEMBL125621 1 5.70
CHEMBL129005 1 5.20
CHEMBL129336 1 -
CHEMBL129006 1 -
CHEMBL125789 1 -
CHEMBL50135 1 -
CHEMBL127108 1 -
CHEMBL125790 1 -
CHEMBL129170 1 -
CHEMBL338840 1 -
CHEMBL340682 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL274447 Kd = 125.89 nM 6.90
CHEMBL129225 Kd = 794.33 nM 6.10
CHEMBL128291 Kd = 1000.0 nM 6.00
CHEMBL339044 Kd = 1584.89 nM 5.80
CHEMBL125621 Kd = 1995.26 nM 5.70
CHEMBL129005 Kd = 6309.57 nM 5.20
CHEMBL129336 Kd >= 10000.0 nM -
CHEMBL129006 Kd > 10000.0 nM -
CHEMBL125789 Kd > 10000.0 nM -
CHEMBL50135 Kd > 10000.0 nM -
CHEMBL127108 Kd > 10000.0 nM -
CHEMBL125790 Kd > 10000.0 nM -
CHEMBL129170 Kd > 10000.0 nM -
CHEMBL338840 Kd > 10000.0 nM -
CHEMBL340682 Kd > 10000.0 nM -