Assay Detail
Functional
CHEMBL652289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of spontaneous contractions in isolated rat uterus
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Uterus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.75 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 10.00 |
| CHEMBL284782 | — | — | 1 | 8.04 |
| CHEMBL544427 | — | — | 1 | 6.28 |
| CHEMBL13560 | — | — | 1 | 5.19 |
| CHEMBL2079599 | — | — | 1 | 4.22 |
| CHEMBL2079543 | — | — | 1 | - |
| CHEMBL3349532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL284782 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL544427 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL13560 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2079599 | — | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL2079543 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3349532 | — | IC50 | > | 100000.0 | nM | - |