Assay Detail
Binding
CHEMBL652293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding of [3H]dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes
21
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.35 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295072 | — | — | 1 | 7.17 |
| CHEMBL42370 | — | — | 1 | 6.96 |
| CHEMBL287587 | — | — | 1 | 6.85 |
| CHEMBL43711 | — | — | 1 | 6.58 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 2 | 6.18 |
| CHEMBL42280 | L-ADRENALINE | — | 1 | 5.43 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 3 | 5.30 |
| CHEMBL295651 | — | — | 1 | 4.62 |
| CHEMBL40796 | — | — | 1 | 4.57 |
| CHEMBL40317 | — | — | 1 | 4.55 |
| CHEMBL40986 | — | — | 1 | 4.42 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 4.30 |
| CHEMBL42359 | — | — | 1 | 4.30 |
| CHEMBL281232 | — | — | 1 | 4.24 |
| CHEMBL40268 | — | — | 1 | - |
| CHEMBL40593 | — | — | 1 | - |
| CHEMBL42216 | — | — | 1 | - |
| CHEMBL41818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295072 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL42370 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL287587 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL43711 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL42280 | L-ADRENALINE | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL295651 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL40796 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL40317 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL40986 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL59 | DOPAMINE | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL42359 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL281232 | — | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL40268 | — | Ki | ~ | 70000.0 | nM | - |
| CHEMBL40593 | — | Ki | ~ | 270000.0 | nM | - |
| CHEMBL42216 | — | Ki | ~ | 90000.0 | nM | - |
| CHEMBL41818 | — | Ki | ~ | 130000.0 | nM | - |