Assay Detail
Binding
CHEMBL652294
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Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]DHA binding in rat lung
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.47 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143463 | — | — | 1 | 8.57 |
| CHEMBL140908 | — | — | 1 | 7.64 |
| CHEMBL341614 | — | — | 1 | 7.06 |
| CHEMBL142635 | NAFTOPIDIL | 4.0 | 1 | 6.00 |
| CHEMBL142474 | — | — | 1 | 5.40 |
| CHEMBL143944 | — | — | 1 | 5.32 |
| CHEMBL143608 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143463 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL140908 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL341614 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL142635 | NAFTOPIDIL | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL142474 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL143944 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL143608 | — | Ki | = | 5300.0 | nM | 5.28 |