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Compound Detail

CHEMBL140908

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CC(C)(C)NCC(O)COc1cccc2c1SCC(=O)N2

Basic Information

ChEMBL ID CHEMBL140908
Phase Preclinical
Structure Type MOL
InChI Key SWWQDUZAPYPHEI-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

310.4
MW (Da)
1.86
ALogP
5
HBA
3
HBD
70.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H22N2O3S
MW 310.42
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -0.43

Activity Summary

Ki 2 meas. best 7.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL3252
Ki 7.7 7.7 20.0 1
Beta-2 adrenergic receptor
CHEMBL2289
Ki 7.64 7.64 23.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10743949 10.1016/s0960-894x(00)00016-0 Adrenergic receptor alpha-1 1
10743949 10.1016/s0960-894x(00)00016-0 Adrenergic receptor alpha-2 1
10743949 10.1016/s0960-894x(00)00016-0 Beta-1 adrenergic receptor 1
10743949 10.1016/s0960-894x(00)00016-0 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine