Assay Detail
Binding
CHEMBL647625
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Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]dihydroalprenolol binding in rat heart
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.91 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143463 | — | — | 1 | 8.28 |
| CHEMBL140908 | — | — | 1 | 7.70 |
| CHEMBL341614 | — | — | 1 | 6.48 |
| CHEMBL142995 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143463 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL140908 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL341614 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL142995 | — | Ki | = | 6700.0 | nM | 5.17 |