Assay Detail
Binding
CHEMBL652347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against AT1 receptor in the presence of 0.01% BSA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.67 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43500 | — | — | 1 | 9.00 |
| CHEMBL297358 | — | — | 1 | 8.96 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | 8.82 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 8.74 |
| CHEMBL42631 | — | — | 1 | 8.52 |
| CHEMBL289448 | — | — | 1 | 8.52 |
| CHEMBL42397 | — | — | 1 | 8.49 |
| CHEMBL45195 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43500 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL297358 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL42631 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL289448 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL42397 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL45195 | — | IC50 | = | 5.3 | nM | 8.28 |