Assay Detail
Binding
CHEMBL652349
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Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of nonpeptide potent conformationally restricted angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.32 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315219 | — | — | 1 | 7.96 |
| CHEMBL316392 | — | — | 1 | 7.82 |
| CHEMBL86935 | — | — | 1 | 7.20 |
| CHEMBL313239 | — | — | 1 | 6.92 |
| CHEMBL88014 | — | — | 1 | 6.72 |
| CHEMBL263967 | — | — | 1 | - |
| CHEMBL314799 | — | — | 1 | - |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | - |
| CHEMBL313945 | — | — | 1 | - |
| CHEMBL314861 | — | — | 1 | - |
| CHEMBL84849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315219 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL316392 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL86935 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL313239 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL88014 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL263967 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL314799 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL191 | LOSARTAN | IC50 | > | 10000.0 | nM | - |
| CHEMBL313945 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL314861 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL84849 | — | IC50 | > | 10000.0 | nM | - |