Assay Detail
Binding
CHEMBL652350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Acyliminothiadiazoline derivatives: New, highly potent, and orally active angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.51 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284918 | — | — | 1 | 9.36 |
| CHEMBL34866 | — | — | 1 | 9.36 |
| CHEMBL35381 | — | — | 1 | 9.18 |
| CHEMBL287116 | — | — | 1 | 8.44 |
| CHEMBL34190 | — | — | 1 | 8.19 |
| CHEMBL35475 | — | — | 1 | 8.14 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | 8.01 |
| CHEMBL286537 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284918 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL34866 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL35381 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL287116 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL34190 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL35475 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL286537 | — | IC50 | = | 37.0 | nM | 7.43 |