Assay Detail
Binding
CHEMBL652351
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Tested for binding affinity against angiotensin II receptor in rat adrenal cortex
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Uracil-based angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.34 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62269 | — | — | 1 | 9.19 |
| CHEMBL416507 | — | — | 1 | 8.85 |
| CHEMBL65503 | — | — | 1 | 8.64 |
| CHEMBL304251 | — | — | 1 | 8.62 |
| CHEMBL303822 | — | — | 1 | 8.48 |
| CHEMBL292781 | — | — | 1 | 8.47 |
| CHEMBL304032 | — | — | 1 | 8.37 |
| CHEMBL292316 | — | — | 1 | 8.35 |
| CHEMBL294358 | — | — | 1 | 8.21 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.09 |
| CHEMBL305350 | — | — | 1 | 7.77 |
| CHEMBL293001 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62269 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL416507 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL65503 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL304251 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL303822 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL292781 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL304032 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL292316 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL294358 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL191 | LOSARTAN | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL305350 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL293001 | — | IC50 | = | 83.0 | nM | 7.08 |