Assay Detail
Binding
CHEMBL652357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% inhibition of [125I]- AII binding to rat liver membrane preparation (AT1)
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Balanced AT1 and AT2 angiotensin II antagonists. III. potent and orally active 5--ketosulfoxide imidazolyl biphenyl sulfonylureas
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 9.86 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313598 | — | — | 1 | 10.70 |
| CHEMBL87244 | — | — | 2 | 10.52 |
| CHEMBL89032 | — | — | 1 | 10.40 |
| CHEMBL315236 | — | — | 1 | 10.40 |
| CHEMBL431853 | — | — | 1 | 10.22 |
| CHEMBL84908 | — | — | 1 | 10.15 |
| CHEMBL91046 | — | — | 1 | 10.10 |
| CHEMBL86538 | — | — | 1 | 10.10 |
| CHEMBL264304 | — | — | 1 | 10.10 |
| CHEMBL87091 | — | — | 1 | 10.05 |
| CHEMBL433010 | — | — | 1 | 10.05 |
| CHEMBL328985 | — | — | 1 | 10.00 |
| CHEMBL84795 | — | — | 1 | 10.00 |
| CHEMBL327927 | — | — | 1 | 9.70 |
| CHEMBL327297 | — | — | 1 | 9.70 |
| CHEMBL91047 | — | — | 1 | 9.52 |
| CHEMBL312990 | — | — | 1 | 9.52 |
| CHEMBL85075 | — | — | 1 | 9.52 |
| CHEMBL316402 | — | — | 1 | 9.46 |
| CHEMBL80370 | — | — | 1 | 9.30 |
| CHEMBL89772 | — | — | 1 | 8.74 |
| CHEMBL315275 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313598 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL87244 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL89032 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL315236 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL431853 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL84908 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL87244 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL91046 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL86538 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL264304 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL433010 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL87091 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL84795 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL328985 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL327927 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL327297 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL91047 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL312990 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL85075 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL316402 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL80370 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL89772 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL315275 | — | IC50 | = | 3.8 | nM | 8.42 |