Assay Detail
Binding
CHEMBL652358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparation
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.21 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89161 | — | — | 1 | 9.15 |
| CHEMBL91465 | — | — | 1 | 8.54 |
| CHEMBL328340 | — | — | 1 | 8.52 |
| CHEMBL314603 | — | — | 1 | 8.51 |
| CHEMBL88663 | — | — | 1 | 8.51 |
| CHEMBL92479 | — | — | 1 | 8.44 |
| CHEMBL313691 | — | — | 1 | 8.43 |
| CHEMBL316063 | — | — | 1 | 8.40 |
| CHEMBL315302 | — | — | 1 | 8.39 |
| CHEMBL261981 | — | — | 1 | 8.38 |
| CHEMBL329887 | — | — | 1 | 8.36 |
| CHEMBL313142 | — | — | 1 | 8.25 |
| CHEMBL420607 | — | — | 1 | 8.19 |
| CHEMBL88170 | — | — | 1 | 8.19 |
| CHEMBL328780 | — | — | 1 | 8.18 |
| CHEMBL88600 | — | — | 1 | 8.15 |
| CHEMBL328997 | — | — | 1 | 8.10 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | 8.09 |
| CHEMBL314605 | — | — | 1 | 8.06 |
| CHEMBL92206 | — | — | 1 | 8.05 |
| CHEMBL315400 | — | — | 1 | 7.96 |
| CHEMBL315401 | — | — | 1 | 7.96 |
| CHEMBL90663 | — | — | 1 | 7.96 |
| CHEMBL315483 | — | — | 1 | 7.85 |
| CHEMBL329655 | — | — | 1 | 7.72 |
| CHEMBL431592 | — | — | 1 | 7.68 |
| CHEMBL265291 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89161 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL91465 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL328340 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL314603 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL88663 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL92479 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL313691 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL316063 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL315302 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL261981 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL329887 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL313142 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL420607 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL88170 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL328780 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL88600 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL328997 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL314605 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL92206 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL315400 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL315401 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL90663 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL315483 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL329655 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL431592 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL265291 | — | IC50 | = | 28.0 | nM | 7.55 |