Assay Detail
Binding
CHEMBL652359
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Inhibitory concentration against AT1 receptor from rat adrenal tissues.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.13 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321531 | — | — | 1 | 9.42 |
| CHEMBL323506 | — | — | 1 | 9.15 |
| CHEMBL96314 | — | — | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321531 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL323506 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL96314 | — | IC50 | = | 1.5 | nM | 8.82 |