Assay Detail
Binding
CHEMBL652360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat cerebral cortex membrane
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.76 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101304 | — | — | 1 | 6.82 |
| CHEMBL103827 | — | — | 1 | 6.70 |
| CHEMBL101192 | — | — | 1 | 6.51 |
| CHEMBL319567 | — | — | 1 | 6.42 |
| CHEMBL321129 | — | — | 1 | 6.34 |
| CHEMBL317415 | — | — | 1 | 6.33 |
| CHEMBL103835 | — | — | 1 | 6.17 |
| CHEMBL451 | CHLORDIAZEPOXIDE | 4.0 | 1 | 6.15 |
| CHEMBL102298 | — | — | 1 | 6.06 |
| CHEMBL101329 | — | — | 1 | 6.05 |
| CHEMBL328386 | — | — | 1 | 5.80 |
| CHEMBL322460 | — | — | 1 | 5.76 |
| CHEMBL99696 | — | — | 1 | 5.75 |
| CHEMBL328407 | — | — | 1 | 5.60 |
| CHEMBL101115 | — | — | 1 | 5.57 |
| CHEMBL100897 | — | — | 1 | 5.57 |
| CHEMBL327961 | — | — | 1 | 5.57 |
| CHEMBL319146 | — | — | 1 | 5.44 |
| CHEMBL319426 | — | — | 1 | 5.39 |
| CHEMBL101169 | — | — | 1 | 5.35 |
| CHEMBL319320 | — | — | 1 | 5.29 |
| CHEMBL103453 | — | — | 1 | 5.28 |
| CHEMBL318094 | — | — | 1 | 5.19 |
| CHEMBL328169 | — | — | 1 | 5.14 |
| CHEMBL103699 | — | — | 1 | 5.10 |
| CHEMBL100866 | — | — | 1 | 5.07 |
| CHEMBL330418 | — | — | 1 | 5.03 |
| CHEMBL103793 | — | — | 1 | - |
| CHEMBL320617 | — | — | 1 | - |
| CHEMBL319785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101304 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL103827 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL101192 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL319567 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL321129 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL317415 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL103835 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL451 | CHLORDIAZEPOXIDE | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL102298 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL101329 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL328386 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL322460 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL99696 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL328407 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL327961 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL100897 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL101115 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL319146 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL319426 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL101169 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL319320 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL103453 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL318094 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL328169 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL103699 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL100866 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL330418 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL100959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL328610 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL318983 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL432004 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL329036 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL422070 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL101065 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103166 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL321305 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL323347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111615 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL319621 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL100816 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL327940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103198 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL102485 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103717 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL100864 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL321805 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL319785 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL320617 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103793 | — | IC50 | > | 10000.0 | nM | - |