Assay Detail
Binding
CHEMBL652369
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Effect on [3H]flunitrazepam binding to Benzodiazepine receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.77 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10483 | — | — | 1 | 9.30 |
| CHEMBL20042 | CGS-9896 | — | 1 | 9.22 |
| CHEMBL1518572 | — | — | 1 | 9.00 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.22 |
| CHEMBL49141 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10483 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL20042 | CGS-9896 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1518572 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL12 | DIAZEPAM | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL49141 | — | IC50 | = | 8.0 | nM | 8.10 |