Assay Detail
Binding
CHEMBL652371
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In vitro displacement of [11C]DAA1106 from PBR (peripheral benzodiazepine receptor) of rat brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.69 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292092 | — | — | 1 | 9.11 |
| CHEMBL63064 | — | — | 1 | 8.79 |
| CHEMBL63065 | — | — | 1 | 8.77 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292092 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL63064 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL63065 | — | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL481537 | PK-11195 | IC50 | = | 8.26 | nM | 8.08 |