Assay Detail
Binding
CHEMBL652372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of radiolabeled antagonist [3H]-Ro- 15-1788 binding to benzodiazepine receptor from rat cortical membranes
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 81 | 7.74 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444045 | — | — | 1 | 9.22 |
| CHEMBL74452 | — | — | 1 | 8.89 |
| CHEMBL306048 | — | — | 1 | 8.85 |
| CHEMBL306342 | — | — | 1 | 8.62 |
| CHEMBL308265 | — | — | 1 | 8.55 |
| CHEMBL308781 | — | — | 1 | 8.47 |
| CHEMBL307957 | — | — | 1 | 8.47 |
| CHEMBL307202 | — | — | 1 | 8.44 |
| CHEMBL74801 | — | — | 1 | 8.42 |
| CHEMBL407 | FLUMAZENIL | 4.0 | 1 | 8.42 |
| CHEMBL75104 | — | — | 1 | 8.41 |
| CHEMBL72321 | — | — | 1 | 8.39 |
| CHEMBL54338 | — | — | 1 | 8.38 |
| CHEMBL73085 | — | — | 1 | 8.28 |
| CHEMBL76465 | — | — | 1 | 8.28 |
| CHEMBL421120 | — | — | 1 | 8.22 |
| CHEMBL307836 | — | — | 1 | 8.21 |
| CHEMBL308035 | — | — | 1 | 8.19 |
| CHEMBL305704 | — | — | 1 | 8.17 |
| CHEMBL74162 | — | — | 1 | 8.16 |
| CHEMBL308359 | — | — | 1 | 8.15 |
| CHEMBL75463 | — | — | 1 | 8.14 |
| CHEMBL73457 | — | — | 1 | 8.12 |
| CHEMBL73795 | — | — | 1 | 8.09 |
| CHEMBL307819 | — | — | 1 | 8.09 |
| CHEMBL307005 | — | — | 1 | 8.08 |
| CHEMBL306088 | — | — | 1 | 8.03 |
| CHEMBL74092 | — | — | 1 | 8.01 |
| CHEMBL74357 | — | — | 1 | 8.01 |
| CHEMBL309091 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444045 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL74452 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL306048 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL306342 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL308265 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL308781 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL307957 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL307202 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL74801 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL407 | FLUMAZENIL | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL75104 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL72321 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL54338 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL76465 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL73085 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL421120 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL307836 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL308035 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL305704 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL74162 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL308359 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL75463 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL73457 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL73795 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL307819 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL307005 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL306088 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL74092 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL74357 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL309091 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL306816 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL74776 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL73292 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL73655 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL74427 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL76167 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL444051 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL75521 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL305830 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL309070 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL308836 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL73624 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL306531 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL307190 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL75216 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL309090 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL310708 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL75315 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL73443 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL74509 | — | IC50 | = | 27.0 | nM | 7.57 |